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A detailed timeline outlining the key phases and experimental events in the study. Abbreviations: PND: Postnatal Day; NG: Naringenin; OFT: Open Field Test; EPM: Elevated Plus Maze; FST: Forced Swim Test; PFC: Prefrontal Cortex; DOPAC: 3,4 Dihydroxyphenylacetic Acid; (5-Hydroxytryptamine); 5-HIAA: 5 Hydroxyindoleacetic Acid; MAO-A: Monoamine Oxidase A; MDA: Malondialdehyde; SOD: Superoxide Dismutase; CAT: Catalase; TT: Total Thiol; Nit: Nitrite; GFAP: Glial Fibrillary Acidic Protein; <t>BDNF:</t> Brain-Derived Neurotrophic Factor; IL-10: Interleukin-10; NSE: Neuron-Specific Enolase.
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Changes in subjective sleep quality and measured serum biomarker. (A) AIS (Athens insomnia index) scores, (B) Peripheral <t>BDNF</t> (Brain derived neurotrophic factor). Data are presented as mean + SE. Significance is considered p < 0.05 after mixed factorial repeated measure ANOVA adjusted with Bonferroni correction for multiple comparisons. *Indicates within-group significance (vs. baseline), ^indicates significant difference between group means (LN19184 vs. placebo). BL (baseline), D (day of testing), LN19184 ( n = 45), Placebo ( n = 42).
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Changes in subjective sleep quality and measured serum biomarker. (A) AIS (Athens insomnia index) scores, (B) Peripheral <t>BDNF</t> (Brain derived neurotrophic factor). Data are presented as mean + SE. Significance is considered p < 0.05 after mixed factorial repeated measure ANOVA adjusted with Bonferroni correction for multiple comparisons. *Indicates within-group significance (vs. baseline), ^indicates significant difference between group means (LN19184 vs. placebo). BL (baseline), D (day of testing), LN19184 ( n = 45), Placebo ( n = 42).
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A detailed timeline outlining the key phases and experimental events in the study. Abbreviations: PND: Postnatal Day; NG: Naringenin; OFT: Open Field Test; EPM: Elevated Plus Maze; FST: Forced Swim Test; PFC: Prefrontal Cortex; DOPAC: 3,4 Dihydroxyphenylacetic Acid; (5-Hydroxytryptamine); 5-HIAA: 5 Hydroxyindoleacetic Acid; MAO-A: Monoamine Oxidase A; MDA: Malondialdehyde; SOD: Superoxide Dismutase; CAT: Catalase; TT: Total Thiol; Nit: Nitrite; GFAP: Glial Fibrillary Acidic Protein; BDNF: Brain-Derived Neurotrophic Factor; IL-10: Interleukin-10; NSE: Neuron-Specific Enolase.

Journal: Current Research in Pharmacology and Drug Discovery

Article Title: Neuroprotective effects of naringenin on nicotine-induced anxiety and depression: Involvement of monoaminergic systems, oxidative stress, and neuroinflammation on male rats

doi: 10.1016/j.crphar.2025.100242

Figure Lengend Snippet: A detailed timeline outlining the key phases and experimental events in the study. Abbreviations: PND: Postnatal Day; NG: Naringenin; OFT: Open Field Test; EPM: Elevated Plus Maze; FST: Forced Swim Test; PFC: Prefrontal Cortex; DOPAC: 3,4 Dihydroxyphenylacetic Acid; (5-Hydroxytryptamine); 5-HIAA: 5 Hydroxyindoleacetic Acid; MAO-A: Monoamine Oxidase A; MDA: Malondialdehyde; SOD: Superoxide Dismutase; CAT: Catalase; TT: Total Thiol; Nit: Nitrite; GFAP: Glial Fibrillary Acidic Protein; BDNF: Brain-Derived Neurotrophic Factor; IL-10: Interleukin-10; NSE: Neuron-Specific Enolase.

Article Snippet: In addition, brain-derived neurotrophic factor (BDNF) was quantified using a specific BDNF ELISA kit from CUSABIO (Cat. No. CSB-E04504r, USA).

Techniques: Derivative Assay

Effects of Naringenin on Neuroinflammatory and Neurodegenerative Markers (A) GFAP levels; (B) BDNF levels; (C) IL-10 levels; (D) NSE levels. Data are expressed as mean ± SEM (n = 8). Significant differences: p < 0.05, ∗ p < 0.01, ∗∗ p < 0.001 vs. vehicle group; + p < 0.05, ++ p < 0.01, +++ p < 0.001 vs. nicotine group.

Journal: Current Research in Pharmacology and Drug Discovery

Article Title: Neuroprotective effects of naringenin on nicotine-induced anxiety and depression: Involvement of monoaminergic systems, oxidative stress, and neuroinflammation on male rats

doi: 10.1016/j.crphar.2025.100242

Figure Lengend Snippet: Effects of Naringenin on Neuroinflammatory and Neurodegenerative Markers (A) GFAP levels; (B) BDNF levels; (C) IL-10 levels; (D) NSE levels. Data are expressed as mean ± SEM (n = 8). Significant differences: p < 0.05, ∗ p < 0.01, ∗∗ p < 0.001 vs. vehicle group; + p < 0.05, ++ p < 0.01, +++ p < 0.001 vs. nicotine group.

Article Snippet: In addition, brain-derived neurotrophic factor (BDNF) was quantified using a specific BDNF ELISA kit from CUSABIO (Cat. No. CSB-E04504r, USA).

Techniques:

Changes in subjective sleep quality and measured serum biomarker. (A) AIS (Athens insomnia index) scores, (B) Peripheral BDNF (Brain derived neurotrophic factor). Data are presented as mean + SE. Significance is considered p < 0.05 after mixed factorial repeated measure ANOVA adjusted with Bonferroni correction for multiple comparisons. *Indicates within-group significance (vs. baseline), ^indicates significant difference between group means (LN19184 vs. placebo). BL (baseline), D (day of testing), LN19184 ( n = 45), Placebo ( n = 42).

Journal: Frontiers in Nutrition

Article Title: A standardized combination of Boswellia serrata and Terminalia chebula extracts to improve cognition in adults with subjective memory complaints: a randomized controlled proof-of-concept study

doi: 10.3389/fnut.2025.1695341

Figure Lengend Snippet: Changes in subjective sleep quality and measured serum biomarker. (A) AIS (Athens insomnia index) scores, (B) Peripheral BDNF (Brain derived neurotrophic factor). Data are presented as mean + SE. Significance is considered p < 0.05 after mixed factorial repeated measure ANOVA adjusted with Bonferroni correction for multiple comparisons. *Indicates within-group significance (vs. baseline), ^indicates significant difference between group means (LN19184 vs. placebo). BL (baseline), D (day of testing), LN19184 ( n = 45), Placebo ( n = 42).

Article Snippet: BDNF, a marker of neuronal maintenance, plasticity, and neurogenesis, was evaluated using the Human BDNF ELISA Kit PicoKine® (Cat# EK0307, Boster Bio, Pleasanton, CA) according to the manufacturer’s instructions.

Techniques: Biomarker Discovery, Derivative Assay